Weight loss product Xenical, its cheap and imported analogues. Xenical analogs and prices Similarity of Xenical

Instructions for use. Contraindications and release form.

INSTRUCTIONS

medical medicine

Xenical

(XENICAL)

Compound:

active ingredient: 1 capsule contains 120 mg of orlistat;

microcrystalline cellulose, sodium starch, sodium lauryl sulfate, povidone K 30, talc;

shell: indigo (E 132), titanium dioxide (E 171), gelatin, printing ink.

Dosage form.

Basic physical and chemical properties: hard gelatin capsules size No. 1, opaque, turquoise color, marked on the body “XENICAL 120”, on the cap - “ROCHE”. The contents of the capsules are granules from white to almost white.

Pharmacological group.

Drugs with a peripheral mechanism of action used for obesity.

ATX code A08A B01.

Pharmacological properties.

Pharmacodynamics.

Orlistat is a powerful and specific inhibitor of gastrointestinal lipases with a long-lasting effect. Its therapeutic effect occurs in the lumen of the stomach and small intestine and consists of the formation of covalent compounds with the active serine site of gastric and pancreatic lipases. The inactivated enzyme then loses its ability to break down food fats that come in the form of triglycerides and influence free fatty acids that are absorbed and monoglycerides.

Pharmacokinetics.

Suction.

A study involving normal weight and obese volunteers showed that the effect on absorption levels was minimal. After 8:00 after oral administration of the drug, unchanged orlistat could not be determined in the blood plasma, which means that its concentration is below the level of 5 ng/mol.

In general, after the use of therapeutic doses, it was possible to detect unchanged orlistat in the blood plasma only sporadically, and its concentrations were extremely low

Distribution.

The volume of distribution cannot be determined because the drug is very poorly absorbed and has no systemic pharmacokinetics that can be determined. In vitro, orlistat is more than 99% bound to plasma proteins (mainly lipoproteins and albumin). In minimal quantities, orlistat can penetrate red blood cells.

Metabolism.

According to data obtained in animal experiments, orlistat metabolism occurs mainly in the walls of the gastrointestinal tract. Approximately 42% of the minimal fraction of the drug that is systemically absorbed in obese patients is accounted for by two main metabolites - M1 and M3.

Molecules M1 and M3 have an open b-lactone ring and inhibit lipase very weakly (1000 and 2500 times less than orlistat, respectively). Given this low inhibitory activity and low plasma concentrations (average 26 ng/ml and 108 ng/ml, respectively) after therapeutic doses, these metabolites are considered pharmacologically inactive.

The main route of elimination is excretion of the drug, not absorbed, in the feces. About 97% of the administered dose of the drug was excreted in the feces, with 83% being excreted as unchanged orlistat.

The cumulative renal excretion of all substances structurally related to orlistat was less than 2% of the administered dose. The time until the drug is completely eliminated from the body (with feces and urine) is 3-5 days. The ratio of orlistat elimination routes in volunteers with normal and overweight was the same. Both orlistat and metabolites M1 and M3 can be excreted in bile.

Indications.

Therapy in combination with a moderately hypocaloric diet in obese patients with a body mass index (BMI) ≥ 30 kg/m2 or overweight patients (BMI ≥ 28 kg/m2), including those who have risk factors associated with obesity.

Treatment with orlistat should be discontinued after 12 weeks if there is no reduction in body weight by at least 5% compared to initial body weight.

Contraindications.

Chronic malabsorption syndrome, cholestasis, hypersensitivity to the active substance or to any other components of the drug, breastfeeding period.

Interaction with other drugs and other types of interactions.

Cyclosporine.

When taking Xenical® and cyclosporine simultaneously, a decrease in plasma concentrations of cyclosporine was observed. This may lead to a decrease in the immunosuppressive effectiveness of cyclosporine. Therefore, simultaneous administration with cyclosporine is not recommended (see Section "Peculiarities of use"). However, if it is impossible to avoid the simultaneous use of orlistat and cyclosporine, it is recommended to more often determine the concentration of cyclosporine in the blood plasma after the administration of orlistat and after its discontinuation in patients receiving cyclosporine. The concentration of cyclosporine in the blood plasma must be monitored until it stabilizes.

Acarbose. In the absence of pharmacokinetic interaction studies, concomitant use of orlistat and acarbose should be avoided.

Anticoagulants for oral administration.

When taking warfarin or other anticoagulants with Xenical®, it is necessary to monitor the international normalization ratio.

Fat-soluble vitamins.

When taken simultaneously with Xenical®, there was a decrease in the absorption of fat-soluble vitamins A, D, E, K. In the vast majority of patients who took part in clinical studies for up to 4 full years of treatment with orlistat, levels of vitamins A, D, E, K and beta carotene remained within the normal range. To ensure proper nutrition, patients on a weight control diet should be advised to include plenty of fruits and vegetables and take multivitamin supplements. If the patient has been recommended multivitamins, they should be taken at least 2:00 after using Xenical® or before bedtime.

Amiodarone.

With the simultaneous use of Xenical and amiodarone, a slight decrease in the level of amiodarone in the blood plasma was observed in a limited number of healthy volunteers. In patients receiving amiodarone, the clinical significance of this phenomenon is unclear, but in some cases it may be clinically significant. Increased clinical and ECG monitoring is recommended in patients receiving orlistat and amiodarone concomitantly.

With the simultaneous use of orlistat and anticonvulsants (valproate, lamotrigine), there have been reports of seizures. A causal relationship has not been established, but patients should be monitored for possible changes in frequency and/or severity.

Rarely, hypothyroidism and/or decreased control of hypothyroidism may occur. The mechanism of this phenomenon has not been proven, however, there may be a decrease in the absorption of iodine salts and / or levothyroxine (see Section “Peculiarities of application”).

Isolated cases of reduced efficacy of HIV antiretroviral drugs, antidepressants and antipsychotics (including lithium) have been reported coinciding with the initiation of orlistat therapy in patients with well-controlled disease. That is why all possible consequences in such patients should be carefully considered before starting treatment with orlistat.

Lack of interaction.

In pharmacokinetic studies with amitriptyline, atorvastatin, biguanides, fibrates, fluoxetine, pravastatin, losartan, phentermine, digoxin, phenytoin, nifedipine GITS (gastrointestinal therapeutic system) and nifedipine slow release. The absence of these interactions has been demonstrated in specific drug interaction studies.

Interaction with oral contraceptives and orlistat has not been demonstrated in specific interaction studies. However, orlistat may indirectly reduce the availability of oral contraceptives and may, in some cases, lead to unexpected pregnancy. In case of severe diarrhea, additional methods of contraception are recommended.

Features of application.

In clinical studies, weight loss with the use of Xenical® was less pronounced in patients with type 2 diabetes mellitus than in patients without diabetes. When using orlistat, it is necessary to monitor treatment with hypoglycemic drugs.

The possibility of adverse reactions from the gastrointestinal tract may increase if Xenical® is used on a diet rich in fat (for example, with a diet of 2000 kcal/day, more than 30% will be calories of fat origin, approximately 67 g of fat). The daily amount of fat should be divided into three main meals.

Cases of rectal bleeding have been reported when using Xenical®. If severe and/or persistent symptoms occur, further evaluation is recommended.

It is necessary to monitor coagulation parameters in patients concomitantly receiving oral anticoagulants (see Section "Interaction with other drugs and other types of interactions").

The use of orlistat may be accompanied by hyperoxaluria and oxalate nephropathy, which sometimes leads to renal failure. This risk is increased in patients with chronic kidney disease and/or decreased circulating fluid volume.

Rarely, hypothyroidism and/or decreased control of hypothyroidism may occur. The mechanism of this phenomenon has not been proven, but there may be a decrease in the absorption of iodine salts and / or levothyroxine (see Section “Interaction with other drugs and other types of interactions”).

In patients with epilepsy, orlistat may disrupt the balance of anticonvulsant therapy by reducing the absorption of antiepileptic drugs, which can lead to seizures (see Section "Interaction with other medicinal products and other types of interactions").

The use of orlistat may potentially reduce the absorption of antiretroviral drugs for HIV-infected patients, and also negatively affect the effectiveness of antiretroviral drugs for HIV-infected patients (see Section "Interaction with other medicinal products and other types of interactions").

Use during pregnancy or breastfeeding.

There are no clinical data regarding the use of orlistat in pregnant women.

Animal studies have shown no direct or indirect negative effects on pregnancy, embryonic/fetal development, childbirth or postnatal development. However, in the absence of clinical data, Xenical® should not be prescribed to pregnant women.

The excretion of orlistat in breast milk has not been studied and should not be used during breastfeeding.

The ability to influence the reaction rate when driving vehicles or other mechanisms.

Does not affect.

Method of administration and dose.

The recommended dose of Xenical® for adults is 1 capsule 120 mg with water immediately before meals during each main meal or no later than 1:00 after meals. If a meal is missed or if the food does not contain fat, then the use of Xenical® can be skipped.

Patients should receive a balanced, moderately hypocaloric diet that contains approximately 30% of calories as fat. A diet rich in fruits and vegetables is recommended. The daily amount of fats, proteins and carbohydrates should be divided into 3 main meals.

Increasing the dose of Xenical® to more than the recommended dose (120 mg 3 times a day) does not lead to an increase in its therapeutic effect. The use of orlistat is accompanied by an increase in the excretion of fat in feces 24-48 hours after taking the drug. After cessation of treatment, fat excretion in feces certainly returns to the level before using Xenical® within 48-72 hours.

The effect of using Xenical® in patients with impaired renal and/or liver function, as well as in children and elderly patients, has not been studied.

Children.

Clinical studies of the use of Xenical® in children (under 18 years of age) have not been conducted.

Overdose.

In clinical studies in individuals with normal body weight and obese patients, the use of single doses of 800 mg of orlistat or repeated use of the drug 400 mg 3 times a day for 15 days was not accompanied by the occurrence of significant adverse events. In addition, obese patients have experience using orlistat 240 mg 3 times a day for 6 months.

Weight correction – this is a difficult and lengthy process. Some people are forced to control their body weight throughout their lives.

To lose weight, you need to change your diet and lifestyle. If this is not enough, diet pills are required.

The accumulation of extra pounds is caused by poor nutrition, overeating, lack of physical activity, metabolic disorders, hereditary predisposition, chronic stress and fatigue.

Weight loss drug Xenical blocks the absorption of fats in the body. As a result, your own fat fiber is consumed, and your weight gradually decreases.

Compound

Xenical is produced by two large pharmaceutical companies ROCHE in Switzerland and Italy.

The release form of the drug is a hard capsule of a bluish tint, each containing 120 mg of active substance.

Markings are in English XENICAL(Xenical), packaged in blisters of 21 pieces, there can be 1-4 blisters in a package.

The main active ingredient of Xenical is orlistat , an inhibitor of gastrointestinal lipases.

When taking this medicine, the human body does not produce specific food enzymes that decompose fats. As a result, triglycerides contained in food do not enter the bloodstream and are not stored in reserve, but are excreted directly along with feces.

An energy deficit occurs, which leads to the consumption of the body's own fat reserves. A concomitant positive effect is manifested in a decrease in blood cholesterol and normalization of insulin levels.

Experts compare the mechanism of action of Xenical with the effect of low-fat, low-calorie diets.

Excipients are binders that ensure the shape and stability of the granules, fillers and disintegrants that promote better dissolution of the drug in the stomach. Fine titanium dioxide and indigo carmine are used as dyes.

There are food preservatives - gelatin, starch, talc, natural dietary fiber in the form of microcrystalline cellulose.

The drug is not absorbed into the blood, therefore it has no effect on internal organs and is not addictive.

Price

Xenical was developed to reduce weight and maintain weight loss results in obese people.

In Europe this drug is sold in pharmacies Requires a doctor's prescription .

You can buy Xenical without a prescription in Russia, but it is better to contact a specialist who will sensibly assess your figure and state of health, help you create a nutrition plan and exercise schedule, and, if necessary, prescribe pills.

How much Xenical costs depends on the location of the pharmacy, pricing policy, and supplies. The average price for a drug is from 1000 to 2000 rubles . You can buy it.

Indications for use

The main indication for the use of Xenical is overweight, if it is more than 30 kg.

The presented medicine is used in the treatment of diseases in which obesity - This is a characteristic accompanying symptom.

Xenical is prescribed for diabetes mellitus, metabolic syndrome, arterial hypertension, atherosclerosis, and metabolic disorders.

Drug assistance in losing weight becomes necessary when fat deposition occurs on internal organs and secretory glands. Most often, this is evidenced by a large belly hanging down.

Instructions for use

For proper and long-term weight loss, experts recommend switching to a healthy and balanced diet, giving up bad habits, and playing sports.

At the same time, Xenical will help move weight off the ground, teach the body to get energy from the right foods, and adjust the caloric content of the diet.

An important rule is the supply of sufficient volume liquids .

Water is necessary for Xenical to work efficiently and quickly in the body. It prevents dehydration, suppresses appetite, and promotes cleansing.

The manufacturer warns that dose increase the drug does not affect its effectiveness.

How to take Xenical:

• a single dose is equal to 1 capsule-tablet of the drug;
• taken during meals or after, no later than an hour later;
• per day, it is permissible to use from 1 to 3 capsules with each meal;
• if the amount of fat in the diet is reduced, then the dose may be minimal;
• The medicine is taken for a three-month course.

The instructions for the drug contain information that Xenical, along with fats removes fat-soluble vitamins from the body necessary to maintain health and maintain normal functioning.

On the advice of specialists and, taking this fact into account, together with Xenical you should take a multivitamin complex.

It is desirable that the vitamin complex contains beta-carotene, vitamins A, E and D, group K.

Reviews of those losing weight

Natalya 42 years old, Vladivostok:

Excess weight has been my big problem since childhood. In my life I have tried everything - diets, from simple to extreme, fasting, special clothes that promote weight loss, earrings for weight loss, pills, hypnosis.

I bought Xenical on the advice of a nutritionist friend. The weight came off slowly but steadily. I liked the drug and lost 9 kg in 3 months.

Side effects included loose stools and increased gas formation. Now I will take Xenical to maintain weight.

Zhanna 34 years old, Voronezh:

I recovered after pregnancy and breastfeeding. I ate practically nothing, and my weight stayed the same. I met a friend and was surprised at how beautiful she looked. She said that Xenical helps her lose weight.

I decided to try it too. The result on the scale is minus 4 kg in 3 weeks. This is just great! I keep losing weight, because I have 16 extra kg. Along with the medication, I switched to proper nutrition, I run in the morning, and I almost completely eliminated sweets and alcohol.

Irina 28 years old, St. Petersburg:

I have congenital diabetes, and by heredity there is a predisposition to obesity.

I heard about Xenical from Malysheva’s program on Channel One. I bought it at the pharmacy and started taking it. The weight began to decrease little by little, I noticed that my intestines were working better, the effect of the pills was obvious. In one week I lost 2 kg and became more cheerful.

Now my result is minus 14 kg in 2 months. I am happy with the medicine and with myself. Xenical really helps you lose weight.

Xenical is an original weight loss product that affects the metabolism of fats in the intestines. It was he who was one of the first to come to the aid of women and men who dreamed of finding a thin waist. However, its significant drawback is its high price.

Let's find out whether there are analogues cheaper than Xenical, what is the difference between them and how to save money on a medicine for weight loss without harm to health.

The capsules are produced by a Swiss company. Contains a gastrointestinal lipase inhibitor - orlistat.

The mechanism of action is due to a specific effect on enzymes that break down fats. By combining with lipases, orlistat neutralizes them, causing them to lose their ability to break down fats contained in food. Thus, fats are excreted unchanged from the intestines along with feces.

Under the influence of the medication, the number of calories entering the body decreases, and body weight gradually decreases.

The use of capsules is justified for the treatment of overweight and obese patients, including those with type 2 diabetes mellitus.

Note! For diabetes, the medicine is combined with hypoglycemic agents.

Losing weight with Xenical is contraindicated in patients with cholestasis, chronic malabsorption syndrome, or hypersensitivity to the components of the drug.

Capsules are not recommended for children, adolescents under 18 years of age, pregnant women, and nursing mothers due to lack of data.

The drug is taken with food, 3 times a day. If there are no fats in the food, then taking the medicine can be skipped.

Note! Exceeding the dosage does not speed up the weight loss process!

Advantages of Xenical:

• Local action- the drug is active only in the lumen of the stomach and small intestine and is not absorbed into the blood. This allows it to be used to treat patients with chronic diseases.
• Fast and long-lasting pharmacological effect- develops after 24 hours, persists for 72 hours.

Packages containing 21, 42 and 84 capsules are available.

Their cost is respectively 900 rubles, 1700 rubles, 3300 rubles.

Xenical's analogs

The original medicine can be replaced with other drugs for weight loss:

• generics (contain a substance identical to Xenical);
• medicines from other pharmacological groups.

GENERICS

The Russian pharmaceutical market offers imported and domestically produced orlistat.

Table of comparative characteristics of generics:

OTHER MEDICINES FOR WEIGHT LOSS

Substitutes differ in composition, mechanism of pharmacological action and contraindications for use.

The most popular analogues are the appetite regulators Reduxin, Goldline, Dietressa and the homeopathic drug Cefamadar.

These medications can be used if you are intolerant or have contraindications to taking Orlistat.

Appetite regulators suppress the feeling of hunger, thereby reducing the amount of food consumed. Reducing calorie levels leads to weight loss. The mechanism of their action is to influence the central nervous system.

To summarize the above

The advantages of the original medicine are clinically proven effectiveness and high quality raw materials.

If someone is not satisfied with the high price of Xenical and wants to buy a cheaper medicine, generics - similar drugs based on orlistat - will come to the rescue. The most affordable and popular among them are Listata and Orlistat, produced in Russia.

Slovenian Orsoten is a little more expensive, but this manufacturer is famous for its high-quality generics. Therefore, if you have a choice about which orlistat to choose, it is better to buy Orsoten or Xenical.

The most powerful substitutes are drugs based on sibutramine - Goldline, Reduxin. However, they are not only more effective, but also more dangerous due to possible negative health consequences. They are dispensed from the pharmacy only with a doctor's prescription.

Note! You can take appetite regulators based on sibutramine only with a doctor's prescription.

The main factors when choosing a replacement are possible contraindications to taking the drug and its quality.

In any case, taking medications for weight loss should be preceded by consultation with a specialist - only he will be able to select the dosage.

Effective and affordable substitutes for Xenical capsules

In medical practice, Xenical is used to overcome obesity, in conjunction with a prescribed diet. People who are preparing to lose weight want to purchase this pharmaceutical product, because the pills will help to lose weight without significant harm to health. However, the price of the medicine will not satisfy many who want to buy it. But you can save a little on the cost by choosing cheaper similar products.

Pharmaceutical effect

Xenical is a powerful inhibitor. The active ingredient is Orlistat. It has a beneficial effect on gastrointestinal lipases. The process of breaking down fats stops and they are not absorbed into the body. This leads to an inevitable decrease in the patient's weight.

Studies of stool fat content have established that the drug in question begins to act after 1-2 days after use. Stopping treatment returns the previous fat content in stool after 2-3 days.

What does the drug help with?

Indications for use:

• Long-term treatment of obesity, including overweight people and people prone to obesity;
• Concurrent use of various hypoglycemic medications in the fight against diabetes.

Who should refuse treatment?

Contraindications:

• Patients with individual intolerance to the active and other components;
• In case of impaired absorption of carbohydrates, proteins and fats by the digestive tract;
• With a decrease or complete cessation of bile formation.

Can it be used by women during pregnancy and lactation?

Due to the fact that there is no verified information from clinical studies about the harm of the drug to the female body who is preparing to give birth to a baby and who is breastfeeding. Accordingly, the medical product is not prescribed.

Negative side effects

In the form of unfavorable processes during therapy, problems with the digestive system may occur. The frequency of bowel movements increases, and stool may become liquid with a high fat content. Less common is a feeling of discomfort in the abdomen and bloating. Patients who are hypersensitive to the drug have allergies of various forms - from a harmless allergic reaction to life-threatening anaphylactic shock.

Treatment rules

How to use Xenical:

It is important to distribute food intake, namely by composition - fats, proteins and carbohydrates, across all three meals per day.

The same dosage is used in patients who combine treatment with other medications - metformin, insulin, and a diet based on a calorie deficit.

If the patient for some reason missed a meal, or the meal does not contain fat, then Xenical should not be used.

The body's reaction to an overdose

Studies have established that frequent use of the drug at a dose of 400 mg three times a day for half a month did not cause severe symptoms in patients.

In the event of an accidental or intentional increase in the dose, undesirable manifestations do not differ from taking the recommended dose. However, in case of overdose, it is necessary to exercise medical supervision throughout the day.

Do I need medical advice before my appointment?

Many people who do not like their physique due to some excess weight want to find different ways to lose weight quickly. Sometimes the right solution for obese people is Xenical tablets. However, it is strictly forbidden to drink them without a doctor’s recommendation. This is due to the fact that existing diseases may worsen while taking the pills. Any diseases associated with impaired functioning of the renal and cardiovascular systems will not ensure favorable weight loss.

Finding ways to buy medicine and jeopardizing your health is not worth it. Only a doctor should determine whether the drug is appropriate.

Features of the treatment process

• By increasing the recommended, established dosage, it is impossible to achieve a positive effect;
• No studies have been conducted on the adverse effects on patients under twelve years of age, as well as those diagnosed with serious pathologies of the liver and kidneys;
• While taking the medication, the patient must eat a balanced diet. Food should be low in calories. The fat content of the product should not exceed 30%. Otherwise, there may be a risk of increased adverse reactions;
• In diabetics, the metabolic process can be improved, which will reduce the dosage of drugs against impaired glucose absorption;
• An enhanced effect can be achieved by taking multivitamins in parallel. They should be drunk before going to bed or two hours after consuming Xenical;
• Drinking alcoholic beverages during treatment is not permitted.

Absorption with other medications

Medicinal substances with which interactions have not been established:

• Atorvastatin;
• Amitriptyline;
• Digoxin;
• Buguanidam;
• Fluoxetine;
• Losartan;
• Various oral contraceptives;
• Warfarin;
• Nifedipine;
• Pravastatin.

When vitamins D, E and beta-carotene are taken together, their absorption is reduced. Multivitamins should be taken no earlier than two hours after taking Xenical or before falling asleep.

Synchronous use of the medication in question with different drugs intended for epilepsy can cause seizures.

Concurrent use of the immunosuppressant Cyclosporine and the antiarrhythmic drug Amiodarone reduces their effectiveness.

Simultaneous treatment with Xenical and Acarbose is not permitted, since the necessary pharmacological studies have not been carried out.

How much does Xenical cost: price at the pharmacy

Sales in pharmaceutical shops - according to doctor's prescription. The cost (on the website apteka.ru, Moscow) is extremely high - for the drug you will have to pay from 1087 (21 capsules per package) to 1791 rubles (42 capsules). In the regions, prices for pharmaceutical products differ insignificantly from those in the capital.

List of inexpensive generics of imported and Russian production

The table shows a list of inexpensive generics of the drug under study:

Listal – (Russian alternative)

Used to combat obesity and excessive body weight. At the same time, you need to follow a calorie deficit diet.

You should not take Listal tablets if you have cholestasis, malabsorption, or problems with normal tolerance of their essential elements. Not recommended for pregnant women and those who are breastfeeding. This is due to the lack of proven evidence of safe treatment.

Taking this pharmaceutical product simultaneously causes some harmful reactions in the body. First of all, the digestive organs are affected, causing diarrhea, abdominal pain, and flatulence. In addition, headaches, respiratory infections, and a general state of weakness are not uncommon.

Orlistat – (Poland)

Another similar medication. Helps against obesity, namely for people with a high body mass index or those who are overweight.

Orlistat capsules are not prescribed to children under twelve years of age who have hypersensitivity to their composition, a chronic form of malabsorption, problems with bile excretion, as well as women expecting a child and breastfeeding.

The most common parallel harmful phenomena are unstable functioning of the gastrointestinal tract, since the absorption of dietary fats is blocked during therapy. They manifest themselves in diarrhea and epigastric pain. There may be a decrease in immunity, which predisposes the body to various infectious diseases - influenza, upper respiratory tract, urinary system. Anxious feelings, migraines, as well as local reactions - rashes on the skin of the body are allowed. Women may experience disruptions to their menstrual cycle.

Orsoten – (Russia/Slovenia)

The cheapest complete analogue of Xenical. Prescribed for long-term treatment of serious weight problems, namely painful obesity and increased body weight.

It is not allowed to be used by patients with allergies to the active substances of Orsoten, diseases of the biliary system, or by women preparing for childbirth or during breastfeeding. It is not issued to minors.

It has many associated reactions of a harmful nature, although mild. They are due to the fact that the drug actively removes fat obtained from food, which leads to dysfunction of the stomach and intestines - severe softening of stools, abdominal pain, increased frequency of bowel movements. A long period of treatment practically prevents these phenomena.

Conclusion on accessible and inexpensive synonyms

The medicine studied in this analytical material stands out for its effectiveness, but at the same time its price is relatively high. On the Russian pharmaceutical market, similar medicines can be purchased cheaper without problems, since they are presented quite well. Domestic and imported pharmaceutical companies produce a number of generics, famous for their high-quality breakdown and blocking the absorption of carbohydrates and fats. An important point in preparing for treatment of weight problems is visiting a qualified nutritionist. His competence includes determining the body mass index, selecting a medication and establishing the recommended dose.

There are restrictions during pregnancy

Has limitations for kidney problems

Xenical is the drug of choice, which is used in the treatment of overweight and obesity. The main substance of this drug is orlistat. It acts on lipases located in the lumen of the gastrointestinal tract. As a result, enzyme activity decreases and fat digestion stops. Contraindications for use are:

• allergy to the components of the drug;
• intrahepatic cholestasis;
• lactation period;
• chronic malabsorption syndrome.

The simultaneous use of Xenical and cyclosporine, acarbose, fat-soluble vitamins, anticoagulants, amiodarone is not advisable, since the effectiveness of the drugs decreases or the risk of side effects increases. When taking Xenical simultaneously with fibrates, amitriptyline, biguanides, oral contraceptives, and alcohol, no interaction was recorded. When choosing cheaper analogues, it is important to take into account that the listed features of Xenical do not always coincide with the substitutes.

The main drug is produced in the form of capsules consisting of gelatin. Complete analogues of Xenical in structure are:

1. Xenalten.
2. Orsoten.

All these drugs have the main active ingredient – ​​orlistat. However, if the price of Xenical and other drugs based on orlistat is not satisfactory, then you can choose a cheaper analogue from those given below. The composition of the listed medications is not identical to the original drug.

Xenalten

According to the pharmacological classification, it belongs to other lipid-lowering drugs. As stated earlier, the main active component of the drug is orlistat. This substance is an inhibitor of lipase, which is produced by the intestines and pancreas.

The effect of orlistat is based on the fact that the body loses the ability to digest lipids from food. Thanks to this, the total caloric intake of food eaten decreases and an energy deficit arises, which encourages you to use your fat reserves. The drug is available in capsule form and is taken enterally. This method of use allows you to deliver the active substance directly to the site of action - the lumen of the small intestine.

The medicine is taken while eating or no more than an hour after. However, if the foods eaten did not contain fats, then taking the capsules can be skipped. The average frequency of use of the medicine is three times a day, but the doctor may change this amount depending on the treatment plan. Xenalten is used for weight loss, subject to diet. It can also be used to maintain body weight after losing weight. Contraindications are:

It is practically no different from the original drug, as it is its complete structural analogue. Side effects most often develop from the gastrointestinal tract. They appear in the form:

• steatorrhea;
• increased urge to defecate;
• changes in stool consistency;
• increased gas formation;
• leucorrhoea and discomfort in the abdomen.

This kind of reaction occurs in the first stages of treatment and goes away on its own. However, they may return again if the diet is not followed. Infections of the respiratory and urinary systems, headaches and weakness may also develop.

Orsoten

This medicine represents a pharmacological group of lipid-lowering drugs with a different mechanism of action. Its active substance is orlistat in the form of a semi-finished product - orsoten. It inhibits enzymes that break down fats, which leads to impaired absorption of lipids from the intestinal lumen.

This helps reduce the concentration of exogenous monoglycerides and free fatty acids. Since lipids carry a large amount of calories, a decrease in their intake into the body leads to energy deficiency and, as a result, to weight loss. When there is a lack of exogenous lipids, the body uses its own stored in fat depots.

The drug is available in the form of capsules containing hypromellose. They must be taken orally, during meals or within an hour after. The average dose prescribed is one capsule 3 times a day. However, if you skip one of the main meals or eat foods that do not contain fat, then taking the medicine can also be delayed.

The indication for use of the drug is obesity in patients suffering from diabetes or predisposed to obesity. Contraindications include:

• allergy to drug components;
• cholestasis;
• pregnancy and lactation;
• age up to 12 years;
• malabsorption.

The differences between Orsoten and the base drug are minimal. Since they have the same active ingredient. The only thing that does not agree with these drugs is the composition of the capsule. If Xenical has gelatin, then Orsoten has hypromellose. Side effects may include:

Porziola

Refers to medications that promote weight loss. Contains polyacrylic acid carbomer as an active component. This substance has the ability to hold liquid, the volume of which is a thousand times greater than its own. This action is aimed at occupying part of the stomach volume with an indigestible component. As a result, satiety occurs after eating a small amount of food.

The less food enters the body, the less energy it will receive. In order to make up for what is missing, he will be forced to use fat reserves. As a result, the patient does not have to change his eating habits and there is no need to follow a diet. However, due to the reduction in the amount of food he receives, he will lose weight.

Porziola is produced in the form of capsules consisting of gelatin. The drug should be taken immediately before meals and washed down with 350 milliliters of water. The average dosage is 2 capsules 1-2 times a day. The amount of medication and the frequency of its administration can be changed by the doctor depending on the treatment tactics. Once in the stomach, the capsule dissolves within ten minutes and the polyacrylic acid carbomer turns into a gel. It remains in this state for 4 hours, so during this time the feeling of hunger does not occur.

The indication for use and purpose of the drug is the treatment of obesity and body weight control. Contraindications include:

• hypersensitivity to the components of the drug;
• gastroesophageal reflux disease;
• gastric ulcer in the acute stage;
• age less than 18 years.

The main drug and Porziol differ in the principle of action and active substance. If in the first case the absorption of fats was inhibited, then in the second the amount of incoming food was reduced. Adverse reactions may include headaches, belching, bloating and changes in stool consistency.

Exadipine

The drug belongs to the group of dietary supplements that are used to reduce body weight. Its active substances are Salacia reticularis root extract and vitamin D3. The action of the first component is to create hypoglycemia. This is achieved by inhibiting the enzymes responsible for digesting carbohydrates. As a result, the amount of incoming glucose decreases, and the body creates it independently from fat reserves. In addition to hypoglycemic activity, the drug strengthens the immune system, prevents acidification of the body and has a cardioprotective effect.

Exadipine is available in capsule form, so it is taken orally. The duration of treatment is determined by the doctor, but on average it is three weeks. To obtain the maximum therapeutic effect, take 1 capsule 3 times a day with meals.

It is possible to change not only the duration, but also the frequency of use of the drug, since the treatment is selected individually by a specialist.

• carbohydrate metabolism disorders in patients with type 2 diabetes mellitus;
• risk of excess body weight;
• to compensate for vitamin D3 deficiency.

Contraindications to taking the drug include: allergies to its components, pregnancy and breastfeeding.

It differs from the main medicine in the direction of action. If Xenical affects lipid metabolism, then Exadipin affects carbohydrate metabolism. Another difference is the naturalness of the composition; if the main drug has synthetic active ingredients, then this analogue is of plant origin. No side effects were identified during the study of the dietary supplement.

Guarem

The drug belongs to the group of substances that lower blood sugar levels with the exception of insulins. Its active ingredient is guar gum. It is produced from the seeds of Cyamopsis quadryptera. In its structure, guar gum is similar to fiber, so the body cannot digest it. In addition, upon contact with water, this substance forms a gel-like substance, which slows down the evacuation of gastric contents.

Thanks to this property, Guarem suppresses the feeling of hunger, since the stomach receptors send signals about the fullness of the organ. In addition, the resin prevents the absorption of carbohydrates from the small intestine, thereby reducing the supply of exogenous glucose. The body reacts to this by synthesizing its own monosaccharide and triglycerides, which are stored in fat depots.

Guarem is produced in the form of granular powder. It is recommended to take 1 scoop 3 times per day with meals. The duration of treatment is prescribed by the doctor on an individual basis. Indications for use of the medicine are:

Contraindications to the use of Guarem are allergies to its components and narrowing of the lumen of any part of the gastrointestinal tract. Unlike the main drug, this analogue does not affect enzymes. Instead, its action is aimed at the absorption of carbohydrates and cholesterol from the lumen of the small intestine. Another difference is the naturalness of the composition; in Guareme the active substance is of plant origin, while in Xenical it is synthetic.

Side effects after using the drug may include flatulence, nausea, abdominal pain, changes in the consistency of stool and allergies. However, these manifestations are mostly temporary and go away on their own.

Metformin

Belongs to the pharmacological group of antidiabetic drugs that are not insulins. The main substance in its composition is metformin hydrochloride. After absorption into the blood, it enters the liver and blocks the AMPK enzyme in it, which is responsible for the synthesis of glucose. In addition to this, the level of glycosylated hemoglobin decreases.

It also acts on tissues, increases their sensitivity to insulin and makes them more actively absorb glucose. Additionally, it reduces the absorption of monosaccharides from the small intestine. As a result of all these actions, blood sugar levels decrease and energy exchange becomes efficient.

The medicine is available in the form of tablets with a dosage of 500/850/1000 milligrams. Treatment generally begins with a minimum dose of the drug and then gradually increases. Metformin is taken 2 or 3 times a day with or after meals. Treatment monitoring occurs 10-15 days from the start of taking the medication.

If the glucose level remains at the same level, then the dosage is increased. However, the daily dose should not exceed 3000 mg, and a single dose should not exceed 1000 mg. The indication for the use of Metformin is type 2 diabetes mellitus, in which diet therapy has proven ineffective and the patient’s body weight continues to increase. Contraindications include:

• diabetic coma and ketoacidosis;
• hypersensitivity to the components of the drug;
• states of shock;
• renal and liver failure.

Metformin, unlike the main drug, does not act locally, but systemically. They also differ in composition and application points. After all, Xenical is aimed at normalizing fat metabolism, and this analogue is aimed at carbohydrate metabolism.

Side effects may include taste disturbances, dyspeptic disorders and decreased appetite.

Type