What is the difference between pancreatin 25 units. Digestive enzyme activity units. Storage conditions and periods
Pancreatin
International nonproprietary name
Dosage form
Enteric-coated tablets, 25 units
Compound
One tablet contains
active substance - pancreatin 0.1 g,
Excipients
core: lactose (milk sugar), gelatin, potato starch, calcium stearate,
shell: cellacephate (cellulose acetylphthalyl), titanium dioxide (titanium dioxide) E171, liquid paraffin (vaseline oil), polysorbate (Tween-80), azorubine (acid red dye 2C)
Description
Tablets are biconvex, coated with a pink or dark pink color, with a specific odor. Two layers are visible in the cross section; inclusions are allowed in the inner layer
Pharmacotherapeutic group
Digestive aids (including enzyme preparations)
Digestive enzyme preparations
ATX code A09AA02
Pharmacological properties
Pharmacokinetics
Pancreatic enzymes are released from the dosage form in the alkaline environment of the small intestine, because protected from the action of gastric juice by the membrane.
The maximum enzymatic activity of the drug is observed 30-45 minutes after oral administration.
Pharmacodynamics
Digestive enzyme agent, replenishes the deficiency of pancreatic enzymes, has proteolytic, amylolytic and lipolytic effects. The pancreatic enzymes included in the composition (lipase, alpha-amylase, trypsin, chymotrypsin) promote the breakdown of proteins into amino acids, fats into glycerol and fatty acids, starch into dextrins and monosaccharides, improve the functional state of the gastrointestinal tract, and normalize digestive processes.
Indications for use
replacement therapy for exocrine pancreatic insufficiency: chronic pancreatitis, pancreatectomy, condition after irradiation, dyspepsia, cystic fibrosis
flatulence, diarrhea of non-infectious origin
impaired digestion of food (condition after resection of the stomach and small intestine)
to improve food digestion in people with normal gastrointestinal tract function in case of dietary errors (eating fatty foods, large amounts of food, irregular meals) and in cases of chewing dysfunction, sedentary lifestyle, prolonged immobilization
Roemheld syndrome (gastrocardiac syndrome)
preparation for x-ray and ultrasound examination of the abdominal organs
Directions for use and doses
The drug is taken orally during or after meals, without chewing and with a non-alkaline liquid (water, fruit juices).
The dose of the drug is set individually depending on age and degree of pancreatic insufficiency. One tablet contains: protease - 25 units, amylase - 1700 units, lipase - 150 units.
Adults usually take 2-4 tablets 3-6 times a day. The maximum daily dose is 16 tablets. The duration of treatment is determined by the attending physician.
Side effects
Allergic reactions
rarely:
Diarrhea, constipation, discomfort in the stomach, nausea (the cause-and-effect relationship of the development of these reactions with the action of Pancreatin has not been established, since these phenomena refer to symptoms of exocrine pancreatic insufficiency)
Hyperuricosuria, hyperuricemia (with long-term use in high doses)
Development of strictures (fibrous colonopathy) in the ileocecal portion of the ascending colon in cystic fibrosis if the required dose of Pancreatin is exceeded
Contraindications
- hereditary fructose intolerance, Lapp enzyme deficiency - lactase, glucose - galactose malabsorption
Hypersensitivity to the components of the drug
Acute pancreatitis, exacerbation of chronic pancreatitis
Pregnancy and lactation
Children and teenagers up to 18 years of age
Drug interactions
When using Pancreatin, the absorption of iron and folic acid may be reduced. The simultaneous use of antacids containing calcium carbonate and/or magnesium hydroxide may lead to a decrease in the effectiveness of Pancreatin.
special instructions
The dose should be adequate to the amount of enzymes necessary for the absorption of fats, taking into account the quality and quantity of food consumed.
Pregnancy and lactation
Since the drug contains a dye prohibited for children (azorubine), it should not be used by pregnant or lactating women.
Tablets "Pancreatin" - an enzyme product. In diseases of the pancreas, it compensates for the insufficiency of its exocrine function and helps improve the digestion process.
Active ingredients
Release form
Pills
Pharmacological effect
Enzyme agent. Contains pancreatic enzymes - amylase, lipase and proteases, which facilitate the digestion of carbohydrates, fats and proteins, which facilitates their more complete absorption in the small intestine. In diseases of the pancreas, it compensates for the insufficiency of its exocrine function and helps improve the digestion process.
Pharmacokinetics
The pharmacokinetics of pancreatin have not been studied.
Indications
Insufficiency of exocrine pancreatic function (including in chronic pancreatitis, cystic fibrosis). Chronic inflammatory-dystrophic diseases of the stomach, intestines, liver, gall bladder, conditions after resection or irradiation of these organs, accompanied by impaired digestion of food, flatulence, diarrhea (as part of combination therapy). To improve the digestion of food in patients with normal gastrointestinal function in case of errors in nutrition, as well as in cases of impaired chewing function, forced long-term immobilization, and a sedentary lifestyle. Preparation for x-ray and ultrasound examination of the abdominal organs.
Directions for use and doses
The dose (in terms of lipase) depends on age and the degree of pancreatic insufficiency. The average dose for adults is 150,000 units/day. In case of complete insufficiency of exocrine pancreatic function - 400,000 units/day, which corresponds to the daily requirement of an adult for lipase. The maximum daily dose is 15,000 units/kg. Children under 1.5 years old - 50,000 units/day, over 1.5 years old - 100,000 units/day. The duration of treatment can vary from several days (if the digestive process is disrupted due to errors in the diet) to several months and even years (if constant replacement therapy is necessary).
The instructions for use describe “Pancreatin 25 units” as an enzymatic digestive drug that is used to treat diseases associated with insufficiency of the exocrine functions of the pancreas.
In what form is it produced?
This medicine takes the form of tablets coated with a special coating that is soluble in the intestinal environment. Sold in cardboard packages, each containing two, three or six blisters. One plate contains ten tablets. Also, these tablets can be sold in dark glass jars containing 60 pills.
Composition of the drug
The instructions for use describe “Pancreatin 25 IU” as a very effective drug, which includes the following components: active substance - pancreatin, gelatin, milk sugar, calcium stearate, titanium dioxide, petroleum jelly, azorubine dye, potato starch, cellacephate and polysorbate.
Many patients ask the question: what does the abbreviation ED stand for? It actually stands for a unit of action.
In what cases can it be used?
"Pancreatin 25 units", the instructions for use of which are described in detail in this article, are very popular among different groups of people, since the product is quite effective and relatively affordable.
Most often, doctors prescribe this drug in the following cases:
For pancreatitis, dyspepsia, after chemical irradiation. That is, in cases where replacement therapy is needed for conditions and ailments associated with imperfect exocrine function of the pancreas;
The drug is very effective in eliminating the symptoms of diarrhea of non-infectious origin, as well as flatulence and (gastrocardiac phenomenon);
In case of improper absorption of food entering the body. This is especially true for the condition after removal of the stomach or small intestine;
The drug can improve digestion. This question is especially relevant for those people who eat poorly, have bad habits, consume a lot of fried, fatty foods and fast foods, as well as for those who lead a sedentary lifestyle;
The medicine is indicated for people who have abnormalities in chewing function, as well as for long-term immobilization.
In some cases, doctors advise using Pancreatin 25 IU tablets, instructions for use for which are included in each cardboard box, for people who are overweight. The active components of the drug promote proper digestion of food and also improve metabolism.
Are there any contraindications for use?
Tablets "Pancreatin Belmed 25 units" instructions for use do not allow everyone to use them. However, there are actually not that many contraindications. Please note the cases in which this product is not recommended for use:
You should not take the drug if you have diseases such as acute or chronic pancreatitis;
The tablets should not be given to children under six years of age;
Do not use the medication under any circumstances if you have noticed hypersensitivity to at least one component included in its composition.
Use for pregnant and lactating women
“Pancreatin 25 units” (instructions for use, reviews are described in this article) is not recommended for use by pregnant women, since there is very little clinical data confirming the safety of the drug for this group of people. Tablets can be prescribed only if the risk to the fetus is not very great.
This medication can be used by breastfeeding women. But in this case, a mandatory consultation with the attending physician is necessary.
"Pancreatin", tablets 25 units: instructions for use
The tablets are usually taken orally with or immediately after meals. The pill should be washed down with plenty of plain water or juice. Do not chew the tablets under any circumstances; swallow them whole.
The dosage is selected individually, and only an experienced specialist can do this, depending on your case.
However, the instructions for use for adults recommend using the drug “Pancreatin 25 units” as follows: from three to six applications per day, two to four tablets. The maximum daily dose is sixteen tablets.
For children, three applications per day will be enough, using one tablet at a time.
The duration of use of this medication depends on each case. If you need to improve digestion without concomitant serious diseases, then a short course of treatment of a few days will be enough.
If your body needs constant replacement therapy, then doctors may prescribe this remedy for you for several months or even years.
It would be useful to say once again that you should not take Pancreatin 25 IU tablets without the recommendation of your doctor. Of course, they are relatively safe, but you must understand the reasons for your poor condition. After all, no one knows, maybe a more serious disease is hidden behind ordinary diarrhea.
Side effects
“Pancreatin 25 units” (the instructions for use allow children to take the drug) in some cases can cause adverse reactions.
Please note that this medication contains components that can lead to allergic reactions. This is especially important to take into account for people suffering from seasonal allergies.
Very rarely, this medication may cause side effects from the digestive system. Some patients experienced nausea, diarrhea, vomiting and abdominal pain. However, the reason for the occurrence of such effects has not been clarified.
In patients suffering from cystic fibrosis, when using the drug "Pancreatin 25 units" in excessively large dosages, strictures in the colon may develop.
Excessive use of the medication can lead to hyperuricosuria and hyperuricemia.
It is very important to choose the correct dosage for children, as otherwise the mucous membranes of the oral cavity may begin to become irritated, and there is also a risk of perianal irritation.
Important instructions
The drug "Pancreatin 25 units" (instructions for use, analogues are listed in this article) cannot be taken in large doses by patients suffering from cystic fibrosis. In this case, there is a high probability of stricture formation.
To determine the correct dosage, you need to take into account the amount of enzymes needed to absorb fats, as well as the quantity and quality of all food consumed. During treatment, it is recommended to follow a diet.
Please note that the drug “Pancreatin 25 units” can reduce the content of iron and folic acid in the body.
Analogs and reviews
This drug is very effective and in demand, so many doctors prescribe it to their patients. However, in some cases, this medicine is not advisable to use, so the patient may be prescribed its substitutes.
The most popular analogues are:
- “Creon 10,000.”
- “Panzim Forte”.
- “Penzital”.
- “Panzikam.”
According to patient reviews, this remedy is very well tolerated and has an amazing effect not only during long-term treatment, but also during express therapy.
In some cases, patients experienced allergic reactions and treatment had to be stopped. There are very rare cases of side effects from the digestive system.
In general, reviews about the drug are positive. Only sometimes patients did not notice the positive effect of treatment. In any case, before using the tablets, consult your doctor and he will help you solve the problem. Don't neglect your health.
Pancreatin
International nonproprietary name
Dosage form
Enteric-coated tablets, 25 units
Compound
One tablet contains
active substance - pancreatin 0.1 g,
Excipients
core: lactose (milk sugar), gelatin, potato starch, calcium stearate,
shell: cellacephate (cellulose acetylphthalyl), titanium dioxide (titanium dioxide) E171, liquid paraffin (vaseline oil), polysorbate (Tween-80), azorubine (acid red dye 2C)
Description
Tablets are biconvex, coated with a pink or dark pink color, with a specific odor. Two layers are visible in the cross section; inclusions are allowed in the inner layer
Pharmacotherapeutic group
Digestive aids (including enzyme preparations)
Digestive enzyme preparations
ATX code A09AA02
Pharmacological properties
Pharmacokinetics
Pancreatic enzymes are released from the dosage form in the alkaline environment of the small intestine, because protected from the action of gastric juice by the membrane.
The maximum enzymatic activity of the drug is observed 30-45 minutes after oral administration.
Pharmacodynamics
Digestive enzyme agent, replenishes the deficiency of pancreatic enzymes, has proteolytic, amylolytic and lipolytic effects. The pancreatic enzymes included in the composition (lipase, alpha-amylase, trypsin, chymotrypsin) promote the breakdown of proteins into amino acids, fats into glycerol and fatty acids, starch into dextrins and monosaccharides, improve the functional state of the gastrointestinal tract, and normalize digestive processes.
Indications for use
replacement therapy for exocrine pancreatic insufficiency: chronic pancreatitis, pancreatectomy, condition after irradiation, dyspepsia, cystic fibrosis
flatulence, diarrhea of non-infectious origin
impaired digestion of food (condition after resection of the stomach and small intestine)
to improve food digestion in people with normal gastrointestinal tract function in case of dietary errors (eating fatty foods, large amounts of food, irregular meals) and in cases of chewing dysfunction, sedentary lifestyle, prolonged immobilization
Roemheld syndrome (gastrocardiac syndrome)
preparation for x-ray and ultrasound examination of the abdominal organs
Directions for use and doses
The drug is taken orally during or after meals, without chewing and with a non-alkaline liquid (water, fruit juices).
The dose of the drug is set individually depending on age and degree of pancreatic insufficiency. One tablet contains: protease - 25 units, amylase - 1700 units, lipase - 150 units.
Adults usually take 2-4 tablets 3-6 times a day. The maximum daily dose is 16 tablets. The duration of treatment is determined by the attending physician.
Side effects
Allergic reactions
rarely:
Diarrhea, constipation, discomfort in the stomach, nausea (the cause-and-effect relationship of the development of these reactions with the action of Pancreatin has not been established, since these phenomena refer to symptoms of exocrine pancreatic insufficiency)
Hyperuricosuria, hyperuricemia (with long-term use in high doses)
Development of strictures (fibrous colonopathy) in the ileocecal portion of the ascending colon in cystic fibrosis if the required dose of Pancreatin is exceeded
Contraindications
- hereditary fructose intolerance, Lapp enzyme deficiency - lactase, glucose - galactose malabsorption
Hypersensitivity to the components of the drug
Acute pancreatitis, exacerbation of chronic pancreatitis
Pregnancy and lactation
Children and teenagers up to 18 years of age
Drug interactions
When using Pancreatin, the absorption of iron and folic acid may be reduced. The simultaneous use of antacids containing calcium carbonate and/or magnesium hydroxide may lead to a decrease in the effectiveness of Pancreatin.
special instructions
The dose should be adequate to the amount of enzymes necessary for the absorption of fats, taking into account the quality and quantity of food consumed.
Pregnancy and lactation
Since the drug contains a dye prohibited for children (azorubine), it should not be used by pregnant or lactating women.
“Pancreatin 25 IU” instructions for use describe it as a digestive enzyme preparation that is used to treat diseases associated with insufficiency of the exocrine functions of the pancreas.
In what form is it produced?
This medicine takes the form of tablets coated with a special coating that is soluble in the intestinal environment. Sold in cardboard packages, each containing two, three or six blisters. One plate contains ten tablets. Also, these tablets can be sold in dark glass jars containing 60 tablets.
Composition of the drug
The instructions for use describe “Pancreatin 25 IU” as a very effective drug, which includes the following components: active ingredient - pancreatin, gelatin, milk sugar, calcium stearate, titanium dioxide, petroleum jelly, azorubine dye, potato starch, cellacephate and polysorbate.
Many patients ask the question: what does the abbreviation OD stand for? It actually stands for a unit of action.
In what cases can it be used?
“Pancreatin 25 units, the instructions for use of which are described in detail in this article, is very popular among various groups of people, since the product is quite effective and relatively affordable. Most often, doctors prescribe this drug in the following cases: - for pancreatitis, dyspepsia, after chemical irradiation. That is, in cases where replacement therapy is needed for conditions and ailments that are associated with imperfect exocrine function of the pancreas;
- the drug is very effective in eliminating the symptoms of diarrhea of non-infectious origin, as well as flatulence and Roemheld syndrome (gastrocardiac phenomenon); - this product is recommended for use before ultrasound or x-ray examination of the digestive system; - in case of improper absorption of food entering the body. This is especially true for the condition after removal of the stomach or small intestine; - the drug can improve digestion. This question is especially relevant for those people who eat poorly, have bad habits, consume a lot of fried, fatty foods and fast foods, as well as for those who lead a sedentary lifestyle; - medications are indicated for people with abnormalities in chewing function, as well as with prolonged immobilization. In some cases, doctors advise using Pancreatin 25 IU tablets, instructions for use for which are included in each cardboard box, for people who are overweight. The active components of the drug promote proper digestion and also improve metabolism.
Are there any contraindications for use?
Tablets "Pancreatin Belmed 25 units" instructions for use cannot be used by everyone. However, there are actually not so many contraindications. Please note the cases in which this product is not recommended to be used:
- you should not take the drug if you have diseases such as acute or chronic pancreatitis; - tablets should not be given to children under six years of age; - Do not use the medication under any circumstances if you have noticed hypersensitivity to at least one component included in its composition.
Use for pregnant and lactating women
“Pancreatin 25 units” (instructions for use, reviews are described in this article) is not recommended for use by pregnant women, since there is very little clinical data confirming the safety of the drug for this group of people. Tablets can only be prescribed if the risk to the fetus is very high.
This medication can be used by breastfeeding women. But in this case, a mandatory consultation with a doctor is necessary.
"Pancreatin", tablets 25 units instructions for use
The tablets are usually taken orally with or immediately after meals. The tablet should be taken with plenty of plain water or juice. Do not chew the tablets under any circumstances; swallow them whole. The dosage is selected individually, and only an experienced specialist can do this, depending on your case.
However, the instructions for use for adults recommend using the drug Pancreatin 25 IU as follows: from three to six applications per day, two to four tablets. The maximum daily dose is sixteen tablets. For children, three applications per day will be enough, using one tablet at a time. The duration of use of this medication depends on each case. If you need to improve digestion without serious concomitant diseases, then a short course of treatment of a few days will be enough. If your body needs constant replacement therapy, then doctors may prescribe this remedy for you for several months or even years.
It would be superfluous to say once again that you should not take Pancreatin 25 IU tablets without the recommendation of your doctor. Of course, they are relatively safe, but you must understand the reasons for your poor condition. After all, no one knows, maybe ordinary diarrhea is hiding a more serious disease.
Side effects
“Pancreatin 25 units” (instructions for use allow children to take the drug) in some cases can cause adverse reactions. Please note that this medication contains components that can lead to allergic reactions. This is especially important to take into account for people suffering from seasonal allergies.
Very rarely, this medication may cause side effects from the digestive system. Some patients experienced nausea, diarrhea, vomiting and abdominal pain. However, the reason for the occurrence of such effects has not been clarified. In patients suffering from cystic fibrosis, when using the drug "Pancreatin 25 units" in excessively large doses, strictures in the colon may develop. Excessive use of the medication can lead to hyperuricosuria and hyperuricemia. It is very important to choose the correct dosage for children, as otherwise the mucous membranes of the oral cavity may begin to become irritated, and there is also a risk of perianal irritation.
Important instructions
The drug Pancreatin 25 units (instructions for use, analogues indicated in this article) cannot be taken in large doses by patients suffering from cystic fibrosis. In this case, there is a high probability of stricture formation. To determine the correct dosage, you need to take into account the amount of enzymes needed to absorb fats, as well as the quantity and quality of all food consumed. During treatment, it is recommended to adhere to a diet.
Please note that the drug Pancreatin 25 units can reduce the content of iron and folic acid in the body.
Analogs and reviews
This drug is very effective and in demand, so many doctors prescribe it to their patients. However, in some cases, this medicine is not advisable to use, so the patient may be prescribed its substitutes. The following analogues are considered the most popular: - “Creon 10000”. - “Panzim Forte”. - “Penzital”. - “Panzikam.” According to patient reviews, this remedy is very well tolerated and has an amazing effect not only during long-term treatment, but also during express therapy. In some cases, patients experienced allergic reactions and treatment had to be stopped. There are very rare cases of side effects from the digestive system. In general, the drug reviews are positive. Only sometimes patients did not notice the positive effect of treatment. In any case, before using the tablets, consult your doctor and he will help you solve the problem. Don't neglect your health.
