Anti-inflammatory drug Diclofenac in tablets - principle of action, side effects and analogues. Diclofenac tablets: instructions for use Taking diclofenac tablets 100 mg

Anti-inflammatory, analgesic, antipyretic, antiplatelet, NSAIDs. Indications: Inflammatory diseases of the musculoskeletal system. Pain syndrome. Orally, without chewing after meals. Adults: 50 mg 1-3 times per day or 75-100 mg once. Max. day. dose? 150 mg.V/m (deep) ? 75 mg (3 ml) 1–2 r per day during 2–5 days

NSAID, phenylacetic acid derivative. It has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect. The mechanism of action is associated with inhibition of the activity of COX, the main enzyme in the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system). Inhibits proteoglycan synthesis in cartilage. For rheumatic diseases, it reduces pain in the joints at rest and during movement, as well as morning stiffness and swelling of the joints, and helps to increase range of motion. Reduces post-traumatic and postoperative pain, as well as inflammatory swelling. Suppresses platelet aggregation. With long-term use it has a desensitizing effect. When applied topically in ophthalmology, it reduces swelling and pain during inflammatory processes of non-infectious etiology.

Articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), degenerative and chronic inflammatory diseases of the musculoskeletal system (osteochondrosis, osteoarthritis, periarthropathy), post-traumatic inflammation of soft tissues and the musculoskeletal system (sprains, bruises). Pain in the spine, neuralgia, myalgia, arthralgia, pain and inflammation after operations and injuries, pain with gout, migraine, algodismenorrhea, pain with adnexitis, proctitis, colic (bilious and renal), pain with infectious and inflammatory diseases of the ENT -organs For local use: inhibition of miosis during cataract surgery, prevention of cystoid macular edema associated with removal and implantation of the lens, inflammatory processes of the eye of a non-infectious nature, post-traumatic inflammatory process in penetrating and non-penetrating wounds of the eyeball.

For oral administration for adults, a single dose is 25-50 mg 2-3 times a day. The frequency of administration depends on the dosage form used, the severity of the disease and is 1-3 times a day, rectally - 1 time a day. For the treatment of acute conditions or relief of exacerbation of a chronic process, a dose of 75 mg is used intramuscularly. For children over 6 years of age and adolescents, the daily dose is 2 mg/kg. Apply externally in a dose of 2-4 g (depending on the area of ​​the painful area) to the affected area 3-4 times a day. When used in ophthalmology, the frequency and duration of administration are determined individually. Maximum daily dose for adults when taken orally it is 150 mg/day.

From the digestive system: nausea, vomiting, anorexia, pain and discomfort in the epigastric region, flatulence, constipation, diarrhea; in some cases - erosive and ulcerative lesions, bleeding and perforation of the gastrointestinal tract; rarely - liver dysfunction. When administered rectally, in isolated cases, inflammation of the colon with bleeding and exacerbation of ulcerative colitis were observed. From the central nervous system and peripheral nervous system: dizziness, headache, agitation, insomnia, irritability, feeling tired; rarely - paresthesia, visual impairment (blurredness, diplopia), tinnitus, sleep disorders, convulsions, irritability, tremor, mental disorders, depression. From the hematopoietic system: rarely - anemia, leukopenia, thrombocytopenia, agranulocytosis. From the urinary system: rarely - renal dysfunction; swelling may occur in predisposed patients. Dermatological reactions: rarely - hair loss. Allergic reactions: skin rash, itching; when used in the form of eye drops - itching, redness, photosensitivity. Local reactions: at the site of intramuscular injection, a burning sensation is possible, in some cases - the formation of infiltrate, abscess, necrosis of adipose tissue; with rectal administration, local irritation, the appearance of mucous discharge mixed with blood, and painful defecation are possible; when used externally in rare cases - itching, redness, rash, burning; when applied topically in ophthalmology, a transient burning sensation and/or temporary blurred vision may occur immediately after instillation. With prolonged external use and/or application to large surfaces of the body, systemic side effects are possible due to the resorptive effect of diclofenac.

Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, “aspirin triad”, hematopoietic disorders of unknown etiology, hypersensitivity to diclofenac and components of the dosage form used, or other NSAIDs.

Use with extreme caution in patients with a history of liver, kidney, gastrointestinal diseases, dyspeptic symptoms, bronchial asthma, arterial hypertension, heart failure, immediately after major surgical interventions, as well as in elderly patients. If there is a history of allergic reactions to NSAIDs and sulfites, diclofenac is used only in emergency cases. During treatment, systematic monitoring of liver and kidney function and peripheral blood patterns is necessary. Rectal use is not recommended in patients with diseases of the anorectal region or a history of anorectal bleeding. It should be used externally only on undamaged areas of the skin. Avoid contact of diclofenac with the eyes (except for eye drops) or mucous membranes. Patients using contact lenses should use eye drops no earlier than 5 minutes after removing the lenses. Not recommended for use in children under 6 years of age. During treatment with dosage forms for systemic use, alcohol consumption is not recommended. Impact on the ability to drive vehicles and machinery During the treatment period, the speed of psychomotor reactions may decrease. If your vision becomes blurred after using eye drops, you should not drive a car or engage in other potentially hazardous activities.

When used simultaneously with diclofenac, antihypertensive drugs may weaken their effect. There are isolated reports of the occurrence of seizures in patients taking NSAIDs and quinolone antibacterial drugs simultaneously. When used simultaneously with GCS, the risk of side effects from the digestive system increases. With simultaneous use of diuretics, the diuretic effect may be reduced. When used simultaneously with potassium-sparing diuretics, it is possible to increase the concentration of potassium in the blood. When used simultaneously with other NSAIDs, the risk of side effects may increase. There are reports of the development of hypoglycemia or hyperglycemia in patients with diabetes mellitus who used diclofenac simultaneously with hypoglycemic drugs. When used simultaneously with acetylsalicylic acid, the concentration of diclofenac in the blood plasma may decrease. Although clinical studies have not established the effect of diclofenac on the action of anticoagulants, isolated cases of bleeding have been described with the simultaneous use of diclofenac and warfarin. With simultaneous use, it is possible to increase the concentration of digoxin, lithium and phenytoin in the blood plasma. The absorption of diclofenac from the gastrointestinal tract is reduced when used simultaneously with cholestyramine, and to a lesser extent with colestipol. With simultaneous use, it is possible to increase the concentration of methotrexate in the blood plasma and increase its toxicity. With simultaneous use, diclofenac may not affect the bioavailability of morphine, however, the concentration of the active metabolite of morphine may remain elevated in the presence of diclofenac, which increases the risk of developing side effects of the morphine metabolite, incl. respiratory depression. When used simultaneously with pentazocine, a case of the development of a grand mal seizure has been described; with rifampicin - a decrease in the concentration of diclofenac in the blood plasma is possible; with ceftriaxone - excretion of ceftriaxone with bile increases; with cyclosporine - increased nephrotoxicity of cyclosporine is possible.

Diclofenac tablets are a non-steroidal anti-inflammatory drug.

It has anti-inflammatory, analgesic, antiplatelet and antipyretic effects. Most effective for inflammatory pain. Used for the symptomatic treatment of diseases of the musculoskeletal system, reducing various types of pain.

On this page you will find all the information about Diclofenac: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Diclofenac tablets. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Conditions for dispensing from pharmacies

Available without a prescription.

Prices

How much do Diclofenac tablets cost? The average price in pharmacies is 20 rubles.

Release form and composition

Tablet forms: tablets in a s/r coating 25 mg, in a p/o coating 25 and 50 mg, retard 100 mg.

• Composition of enteric-coated tablets: 25 or 50 mg Diclofenac sodium, disubstituted calcium phosphate, starch, magnesium stearate, polyvinylpyrolidone K30, purified talc, cellulose acetate, indoresin, diethyl phthalate, carmoisin varnish, titanium dioxide, Ponceau 4R varnish, red and yellow iron oxide .

Pharmacological effect

Suppresses the exudative and proliferative phases of inflammation. Reduces the amount of serotonin, histamine and bradykinin, increases the threshold for the perception of pain receptors; reduces the concentration of PG in the center of thermoregulation, increases heat transfer, reduces body temperature; inhibits platelet aggregation.

Indications for use

The tablet form of Diclofenac is prescribed to relieve pain during attacks of psoriatic, gouty, juvenile, ligament and articular injuries of the knee joint.

Tablets can be used for pain in the spine. Arising as a result of degenerative changes in intervertebral discs. Used for carpal tunnel syndrome or elbow joint. Indispensable in case of injury, sprain or dislocation, including among athletes and people working in physically demanding industries.

Contraindications

Contraindications to the use of tablets:

• inflammatory bowel diseases;
• exacerbation of gastrointestinal lesions (erosive-ulcerative);
• bleeding from the gastrointestinal tract;
• severe renal or liver failure;
• condition after coronary artery bypass surgery;
• pregnancy and lactation;
• “aspirin triad” – intolerance to NSAID drugs in patients with bronchial asthma and nasal polyps;
• children under 6 years of age for 25 mg tablets, other dosages are contraindicated under 18 years of age;
• lactose intolerance, lactase deficiency, glucose-galactose absorption pathologies.

Prescribed with caution for the following conditions: inflammatory bowel disease, alcoholism, chronic erosive and ulcerative diseases of the gastrointestinal tract (not exacerbation), diabetes, diverticulitis, inducible porphyria, bronchial asthma, anemia, congestive heart failure, edema syndrome, arterial hypertension, liver or kidney failure , condition after major surgical interventions, old age, systemic pathologies of connective tissue.

Use during pregnancy and lactation

Contraindicated in the third trimester of pregnancy. In the first and second trimesters of pregnancy it should be used according to strict indications and in the lowest dosage.

Diclofenac passes into breast milk. If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped.

Instructions for use

The instructions for use indicate that Diclofenac in tablet form should be taken orally, without chewing and with a sufficient amount of water, preferably 30 minutes before meals (to achieve a quick therapeutic effect). It is also possible to take the drug before, during or after meals.

• For children over 15 years of age and adults, Diclofenac is prescribed 2-3 times a day, 25-50 mg (maximum 150 mg per day). After improvement, the dose is gradually reduced and switched to maintenance therapy - 50 mg per day.

When treating juvenile rheumatoid arthritis, the daily dose can be increased to 3 mg/kg body weight.

For children, the drug is usually prescribed in the following doses (single/daily):

• 6-7 years (20-24 kg) – 25/25 mg;
• 8-11 years (25-37 kg) – 25/50-75 mg;
• 12-14 years (38-50 kg) – 25-50/75-100 mg.

How long can it be used?

Most pathologies and complications associated with the use of this drug occur during the duration of treatment. How to take Diclofenac tablets to prevent the appearance of unpleasant symptoms? First of all, the process must be supervised by a doctor. Adult patients are prescribed 2-3 tablets per day. The dose is reduced as improvements occur.

The duration of treatment should not exceed 2 weeks, with the exception of complex cases.

Side effects

When taken orally, the following side effects are possible: dyspepsia, erosive and ulcerative lesions of the digestive canal, perforation of its walls, gastric and intestinal bleeding, increased drowsiness, dizziness, hypersensitivity reactions, irritability.

Overdose

Symptoms: Hypotension, renal failure, seizures, gastrointestinal irritation or respiratory depression may occur.

Treatment: There is no specific antidote. In case of acute poisoning, it is necessary to stop the absorption of the drug from the gastrointestinal tract as soon as possible. Gastric lavage, administration of activated charcoal and other symptomatic and supportive therapy are indicated. The use of forced diuresis, dialysis or blood transfusion is poorly justified, due to the fact that NSAIDs are highly bound to serum proteins and have extensive metabolism.

special instructions

During treatment with the drug, systematic monitoring of peripheral blood, liver and kidney function, and stool examination for the presence of blood should be carried out.

Patients taking the drug must refrain from activities that require increased attention and rapid mental and motor reactions, and alcohol consumption.

Drug interactions

1. Reduces the effect of hypoglycemic drugs.
2. Reduces the effects of antihypertensive and hypnotic drugs.
3. Acetylsalicylic acid reduces the concentration of diclofenac in the blood.
4. Increases plasma concentrations of digoxin and methotrexate. lithium and cyclosporine drugs.
5. Concomitant use with paracetamol increases the risk of developing nephrotoxic effects of diclofenac.
6. Cefamandole, cefoperazone, cefotetan, valproic acid and plicamycin increase the incidence of hypoprothrombinemia.
7. Cyclosporine and gold preparations increase the effect of diclofenac on the synthesis of prostaglandins in the kidneys, which increases nephrotoxicity.
8. Simultaneous administration with ethanol, colchicine, corticotropin and St. John's wort preparations increases the risk of bleeding in the gastrointestinal tract.
9. Reduces the effect of diuretics; against the background of potassium-sparing diuretics, the risk of hyperkalemia increases; against the background of anticoagulants, thrombolytic agents (alteplase, streptokinase, urokinase) - the risk of bleeding (usually from the gastrointestinal tract).
10. Diclofenac enhances the effect of drugs that cause photosensitivity. Drugs that block tubular secretion increase the plasma concentration of diclofenac, thereby increasing its toxicity.
11. Increases the likelihood of side effects of other NSAIDs and glucocorticosteroids (bleeding in the gastrointestinal tract), the toxicity of methotrexate and the nephrotoxicity of cyclosporine.

Joint pain and sports injuries cause a person considerable discomfort, which interferes like an annoying fly and prevents him from returning to a full life. The list of the most effective means for eliminating pain, according to experts, is headed by Diclofenac tablets.

Properties of Diclofenac tablets

This form of Diclofenac is the best choice for quickly eliminating inflammation and pain, as well as reducing the temperature in the affected area.

The active component Diclofenac inhibits the formation of an enzyme that provokes the development of inflammation and pain.

For rheumatic pathologies, the medication helps eliminate limited movement, which manifests itself in the morning, relieves swelling, and restores the functionality of the joints.

Taking Diclofenac after joint deformation and surgical operations shortens the period of complete restoration of body tissues, reduces swelling and relieves pain.

The maximum effect of the drug is achieved 10 days after the start of therapy.

Composition and release form

The release form of the medicine is long-acting (prolonged) action tablets, coated.

The photo shows a package of Diclofenac tablets

The composition of 100 grams of the product is as follows:

• active substance: diclofenac sodium – 0.1 grams;
• additional substances: hypromellose, microcrystalline cellulose, magnesium stearate, colloidal silicon dioxide.
• tablet shell: talc, titanium dioxide, macrogol, polyvinyl alcohol, dye.

The mass of one tablet is 0.257 grams: 0.25 grams is a tablet without a shell, 0.007 is the mass of a shell.

When is use indicated?

1. Rheumatology. For the first time, Diclofenac was used specifically in the treatment of rheumatic pathologies. The drug is as safe as possible for the victim and effectively helped eliminate pain. Today, Diclofenac is also popular in the fight against pathologies such as arthritis and arthrosis.
2. Orthopedics, traumatology, sports medicine. Diclofenac has proven itself to be effective in eliminating mild and severe pathologies of the musculoskeletal system: pain quickly disappears. In a variety of cases, the treatment regimen allows you to combine Diclofenac with medications of different release forms. Thus, it is possible to achieve maximum effect and minimize the risk of unwanted effects.
3. Neurology. Diclofenac is often used to relieve discomfort in the back and severe headaches.

Contraindications

1. Peptic ulcer disease.
2. Bleeding in the gastrointestinal tract.
3. Failures in the process of blood synthesis.
4. Aspirin asthma.
5. Failures in the hemostasis system.
6. Pregnancy, mainly the third trimester, lactation.
7. Preschool children.
8. Immunity to individual components of the product.

Diclofenac is taken carefully and under constant medical supervision for:

• anemia;
• asthma;
• heart pathologies;
• liver and kidney failure;
• inflammatory bowel pathologies;
• diabetes;
• age over 65 years;
• connective tissue pathologies.

Note: throughout the course of Diclofenac therapy, it is important to monitor the state of the blood, liver and kidney activity. In addition, for the period of treatment it is better to exclude activities that require concentrated attention and precise reactions, and give up alcohol.

Course of treatment: instructions for use

Diclofenac tablets, which have a long-lasting effect, are a special form of medication. After administration, the active substance Diclofenac is released more slowly than in other medications of similar properties. As a result, the effect occurs somewhat later, but lasts much longer.

This feature of the tablets allows you to reduce the daily dosage of the drug and maintain the maximum concentration of Diclofenac in the lesion. Such tablets can be used to eliminate pain that has transformed into chronic pain.

The initial permissible dose for adults is 75 mg, in other words, 1 tablet per day. This amount of Diclofenac is quite enough to treat a mild form of the disease, for example, when symptoms are most pronounced in the morning or evening.

Note: Diclofenac tablets with a double shell are available today. One tablet consists of a fast (prolonged) action component (12.5 mg) and a slow action component (62.5 mg).

How to take the drug

Adults are prescribed one or two tablets two to three times a day. When improvement occurs, the dosage of Diclofenac is reduced to two tablets per day.

Children over six years old can take no more than 25 mg per day (1 tablet), the dose is divided into two or three doses. It is allowed to increase the dosage for children with juvenile rheumatoid arthritis.

The course of therapy with Diclofenac tablets does not exceed two weeks. Further treatment must be agreed with a specialist.

Approximate treatment regimen with Diclofenac tablets:

Age	Weight	One-time rate	Norm per day
From 6 to 7 years	From 19 to 25 kg	1 tablet (25 mg)	1 tablet (25 mg)
From 8 to 11 years	From 26 to 38 kg	1 tablet (25 mg)	2-3 tablets (50-75 mg)
From 12 to 14 years	From 39 to 50 kg	1-2 tablets (25-50 mg)	3-4 tablets (75-100 mg)
Adults		1-2 tablets (25-50 mg)	2-6 tablets (50-150 mg)

Overdose and side effects

In case of an overdose, the patient experiences headache, vomiting, and shortness of breath. Children may develop seizures, bleeding, and disruptions in the functioning of the liver and kidneys.

Treatment includes gastric lavage, activated charcoal and forced diuresis.

Side effects:

1. From the gastrointestinal tract: sensations of bloating, increased flatulence, lack of stool (constipation). In difficult situations, gastrointestinal bleeding develops. Jaundice, hepatitis, cirrhosis, and pancreatitis occur extremely rarely.
2. From the nervous system: frequent headaches and dizziness, sleep disturbances, or vice versa - drowsiness and a feeling of fatigue, a feeling of fear.
3. From the senses: mind in the ears, visual impairment.
4. On the skin side, the following may be observed: itching and rash, urticaria, dermatitis, increased photosensitivity.
5. From the genitourinary system there are: fluid retention, hematuria, necrosis, nephritis, azotemia.
6. On the part of the hematopoietic organs and immune system, the following may develop: anemia, extremely rarely - leukopenia, exacerbation of infectious processes.
7. From the respiratory system: cough, pneumonitis and laryngeal edema are possible.
8. From the cardiovascular system the following are observed: unstable blood pressure, pain in the chest area, heart failure.

Allergic reactions in the form of anaphylactic shock, swelling of the tongue and lips are also possible.

Interaction

• The medication is able to influence the concentration in the blood plasma of substances such as digoxin and lithium preparations towards an increase.
• The pharmacological properties of diuretics may decrease. The risk of a sharp increase in potassium levels in the blood and gastrointestinal bleeding increases.
• The effect of sleeping pills is neutralized.
• The risk of negative effects from taking other non-steroidal drugs that relieve inflammation increases significantly.
• Aspirin reduces the properties of Diclofenac, as it affects the concentration of the active component in the blood towards a decrease.
• Paracetamol exhibits the nephrotoxic properties of Diclofenac more intensely.
• Diclofenac is able to neutralize the properties of hypoglycemic agents.
• Gold preparations contribute to the manifestation of diclofenac nephrotoxicity.
• The active substance Diclofenac increases the pharmacological properties of medications that cause the body's sensitivity to ultraviolet radiation.

Price

The cost of the drug is affordable to buyers with different income levels, but varies depending on the form of release, the manufacturer and the city where the pharmacy is located.

On average, the price of 100 mg Diclofenac tablets in Russia is 45 rubles, in Moscow – 63 rubles.

Analogs

Today, specialists have the opportunity to choose Diclofenac-based drugs in various dosage forms, thus selecting the most effective therapy for the patient.

Name	Release form	Manufacturer	Price
	Emulgel	Novartis, Switzerland	452 rubles
Diklak	Gel	Salutas Pharma GmbH, Germany	245 rubles
Diklovit	Gel	Nizhpharm, Russia	107 rubles
Dicloran	Gel	Unique Pharmaceutical, India	200 rubles
Diclofenacol	Cream	Hyperion SA, Romania	73 rubles
Naklofen	Pills	KRKA, Novo Mesto, Slovenia	97 rubles

Thus, the patient can choose the drug that is most comfortable to use.

Nonsteroidal anti-inflammatory drug (NSAID) Diclofenac 100 belongs to a group of medications that have pronounced anti-inflammatory and analgesic properties. The use of the drug for therapeutic and prophylactic purposes is permitted when a patient is diagnosed with diseases of the musculoskeletal system of various etiologies. The medication has several forms of release, each of which has its own advantages. The instructions for use indicate possible contraindications.

Release form, composition and packaging

The drug has 4 release forms. These include:

• solution for intramuscular administration.
• pills;
• candles;
• capsules;
• gel.

The active ingredient is diclofenac sodium, the same for all dosage forms. The content of the active component in 1 unit varies from 25 mg to 100 mg. Solution for injection is a clear yellowish liquid without a specific odor. 1 ml of the drug contains no more than 25 mg of the active element.

The auxiliary components in the injection solution include ethylene glycol polymer, acetylcysteine, sodium hydroxide, propylene glycol and purified water. The solution is poured into clear glass ampoules. The package contains 5 ampoules.

Pills

Round red-orange pills, coated with a film, have a prolonged effect. The tablets contain 100 mg of diclofenac sodium and a number of additional components, including sucrose, colloidal silicon dioxide, povidone and talc. The presence of dyes in the film shell (crimson and brown) is provided by the manufacturer. Contour blister packs hold 10 pills. The number of blisters in a package varies from 1 to 3 pcs.

Candles

The cylindrical torpedo-shaped rod has a cream color. The surface of the suppository is smooth, which facilitates administration. The content of the active ingredient is 50 mg in 1 suppository. Additional elements: anhydrous colloidal silicon dioxide and triglyceride. The presence of solid fat in the suppository is mandatory.

The package contains 10 rods. The number of suppositories is divided into 2 equal parts - 5 in each blister.

Capsules

Diclofenac-Ratiopharm Retard in capsule form is produced in Germany. Inside the oblong gelatin case there is a granular yellowish powder. The cover and body of the case may vary in color. The content of the active element in 1 unit does not exceed 100 mg.

Auxiliary components act as stabilizers of the active substance. These include lactose monohydrate, microcrystalline cellulose, glycerol trimestate, triethyl citrate. There are 10 capsules in cellular packaging.

Gel

This release form is intended for external use. The product is a yellowish gel-like mass with a pungent odor. The dosage form has the lowest content of the active ingredient - 10 mg. Additional elements add viscosity to the mass and ensure rapid penetration of the gel into soft tissues. These include:

• trolamine;
• purified water;
• nipagin;
• lavender oil;
• carbopol.

The paste-like mass is sold in aluminum tubes of 30 and 50 g. The tubes are placed in cardboard packages.

pharmachologic effect

The non-steroidal anti-inflammatory drug is a derivative of phenylacetic acid. It has pronounced analgesic, antipyretic and anti-inflammatory properties. The mechanism of action (regardless of the release form) is based on the ability of the drug to inhibit the activity of cyclooxygenase.

Metabolites of arachidonic acid are directly involved in inflammatory processes, and the drug affects them.

The peripheral and central mechanisms provide the analgesic effect. When using the medication for medicinal purposes in diseases of a rheumatic nature, a decrease in pain and swelling is observed. Reduces inflammation and pain after surgery.

The maximum concentration in the blood is achieved after 40-120 minutes with rectal and intramuscular administration, after 2-3 hours with oral administration. Metabolized in the liver. The elimination period takes 1.5-2 hours. 99% binds to blood proteins. There is no cumulation.

Indications for use of Diclofenac 100

The use of the drug is permitted for diseases accompanied by inflammation of the joints. Indications for use prescribed in the instructions include arthritis (chronic, rheumatoid and juvenile), spondylitis, gout, bursitis, ankylosing spondylitis, myalgia, rheumatism, neuralgia, lumbago and radiculitis.

Use is permitted in orthopedics and dentistry after surgery. The medication can be included in complex therapy for otitis, tonsillitis and pharyngitis. The use of any form of release does not affect the progression of the disease.

How to use Diclofenac 100

Tablets and capsules are taken orally whole after meals, washing down the pills with a sufficient amount of liquid. The recommended therapeutic dose is 100 mg per day, which is equivalent to 1 pill. The medication must be taken at the same time every day (preferably at night). It is not recommended to skip a dose.

Rectal suppositories must be inserted into the rectum before bed. This will relieve night pain and avoid morning stiffness. The permitted therapeutic dose should not exceed 50 mg of the active ingredient per day (no more than 2 injections).

The course of treatment should not exceed 10 days. It is recommended to start treatment with small doses. Compliance with the dosage regimen is mandatory.

Discontinuation should be gradual; you cannot abruptly stop taking it.

Side effect

Side effects develop due to improper use or non-compliance with the doctor’s instructions. From the digestive system, bleeding in the gastrointestinal tract, epigastric pain, dyspepsia, attacks of nausea and vomiting may develop. The development of peptic ulcer disease is observed in rare cases. In 3% of cases, the patient is diagnosed with hemorrhagic colitis, pancreatitis and fulminant hepatitis.

Disorders of the nervous system are expressed by dizziness, headaches, sleep disturbances (drowsiness or insomnia), memory loss, tremors of the limbs, convulsions and anxiety. In rare cases, the patient's cerebral circulation is disrupted, depression develops, and the emotional background is disturbed.

From the sensory organs, vertigo is observed: hearing and vision impairment, tinnitus and diplopia. Pathologies of the respiratory system may appear, including asthma attacks and asthma. Renal failure, angioedema (Quincke's edema) and anaphylactic shock are considered side effects. If used incorrectly, the risk of developing myocardial infarction and other thrombotic complications increases.

Contraindications to the use of Diclofenac 100

The use of the drug for therapeutic and prophylactic purposes is unacceptable in the following cases:

• bronchial asthma;
• exacerbation of stomach and duodenal ulcers;
• bearing a child, especially the last trimester;
• childhood;
• hypersensitivity to individual components of the drug.

Pathologies requiring careful use:

• history of gastric bleeding;
• Crohn's disease;
• respiratory tract infections;
• diabetes;
• cerebrovascular diseases;
• hepatic porphyria.

Suppression of muscle tissue contractility can be observed in patients with mild dystrophy.

special instructions

The active component passes into breast milk in small quantities. It is not recommended to take capsules and tablets with sweet or carbonated drinks. Patients with a history of anorectal bleeding are prohibited from using rectal suppositories. Systematic monitoring of kidney and liver function is mandatory. The medication is not compatible with alcohol.

Use during pregnancy and breastfeeding

Carrying a child and breastfeeding are absolute contraindications.

Use in children

Use on patients under 18 years of age is prohibited.

How to take if you have kidney problems

Overdose

There is no reliable information about drug overdose.

Drug interactions

The simultaneous use of drugs that eliminate the increase in blood pressure and NSAIDs is prohibited. Medicines used for medicinal purposes for kidney diseases, in combination with NSAIDs, increase the risk of developing nephrotoxic kidney damage. The medication enhances the effect of antitumor drugs (Plicamycin, Rovamycin). Concomitant therapy with anticoagulants and NSAIDs may cause internal bleeding.

Storage conditions and periods

The optimal storage temperature for any dosage form is considered to be 20°C. The storage location should be cool, dry and out of reach of children. Shelf life – 48 months.

Conditions for dispensing from pharmacies

Any of the dosage forms requires a prescription from pharmacies (except for gel for external use).

Price

The cost starts from 120 rubles.

Analogs

The medication has several structural substitutes with a therapeutic effect similar to the original. The most popular analogues:

1. Voltaren. Rectal suppositories. Belongs to the group of non-steroidal anti-inflammatory drugs. Effective for diseases of the musculoskeletal system accompanied by inflammatory processes. The content of the active component is no more than 50 mg. Estimated cost – from 300 rubles.
2. Naproxen. A long-acting, broad-spectrum drug, the therapeutic effect is the same as that of Diclofenac. Used for joint diseases. Available in tablet form. Approximate price – about 85-100 rubles.
3. Ketoprofen. Available in the form of an ointment for external use. An effective drug with anti-inflammatory and analgesic effect. Indications for use include arthritis, lumbago, gout, radiculitis. Cost at the pharmacy - from 250 rubles.
4. Arthrozan. The drug belongs to the selective inhibitors of cycloorganase (COX 1). The anti-inflammatory medication is available in the form of an injection solution. Direct analogue of Diclofenac in injections. Cost in pharmacies – from 740 rubles.

If necessary, an analogue is selected by a specialist. Independent selection of a substitute is prohibited.

When the pain hits you, you need to urgently look for a remedy that will help get rid of it. Having Diclofenac tablets in your home medicine cabinet will be a salvation in such a situation. How this drug works, in what cases it helps, features of its use and contraindications - the information from the article will help you get answers to all your questions.

The active component of the drug is diclofenac, which belongs to the group of NSAIDs, namely phenylacetic acid derivatives. Medicines based on this substance include a sodium salt compound.

Among several forms of release of this drug, the most convenient for storage and use is tablet form.

You can buy different types of pills in pharmacies without a prescription:

• regular tablets with 25 mg of active ingredient;
• enteric form with an increased amount of diclofenac - 50 mg;
• extended-release capsules - 100 mg.

The word “conventional” refers to drugs that have a simple shell based on starch, povidone and magnesium stearate. It begins to dissolve quickly immediately after ingestion, along the path of the digestive tract. Round, convex tablets have an orange shell and a white inside.

Diclofenac retard capsules (from the English retard - “delay”, “slow down”, “delay”) act much more slowly.

The tablets are coated with a pink film based on hyaetellose, which ensures gradual dissolution of the drug. That is, after taking the tablet, there is not an immediate release of the active component, but its regular release over a long period of time.

Tablets are packaged in packages of 20, 30, 50 or 100 pieces. One blister can hold 5, 10 or 20 pills.

Pharmacological properties and pharmacokinetics

Prostaglandins - mediators that increase the sensitivity of receptors to pain perception - are produced in the body by certain enzymes. The sodium salt of phenylacetic acid inhibits the appearance of this enzyme (cyclooxygenase), reducing pain by reducing the rate of the inflammatory process.

The drug has a complex effect on the source of pain and general condition:

• anesthetizes;
• relieves swelling;
• slows down the further development of the inflammatory process;
• brings down the temperature;
• reduces the likelihood of allergic reactions.

Immediately after taking the tablets they begin to act. The active substance from regular tablets reaches its maximum concentration in the blood after 2 hours, and after consuming extended-release capsules - after 4.

Diclofenac stands out among other anti-inflammatory drugs due to its high efficiency and speed of action. Its antipyretic and analgesic effect is especially predominant.

After absorption and impact on the production of enzymes, about 60% of the drug is excreted in metabolized form in the urine, the rest is excreted along with bile. Only 0.5 - 1% of the drug is excreted unchanged.

What do Diclofenac tablets help with?

At the beginning of its appearance, in the 60s of the last century, the drug was used exclusively for the treatment of various rheumatological diseases.

Among them:

• intervertebral hernia;
• arthritis of various origins;
• osteochondrosis;
• gout;
• radiculitis;
• inflammation of muscles and joints;
• spondyloarthritis;
• rheumatism;
• bursitis;
• osteoarthritis.

Gradually, the scope of use of the drug expanded.

Now the drug is prescribed by doctors of various specializations to relieve pain and eliminate inflammatory processes of various origins.

You can take Diclofenac:

• in the presence of neuralgic symptoms;
• to eliminate migraines;
• with myalgia;
• after surgery to reduce pain;
• for toothache;
• with inflammation of the pelvic organs;
• for painful periods in women;
• with proctitis, prostatitis;
• after injuries, sprains (including sports);
• to reduce the symptoms of acute infectious diseases - sinusitis, otitis, pharyngitis;
• for inflammation of the eyes;
• for relief of acute liver pain.

In each case, when deciding to take the drug, it is necessary to base it on the severity of the symptoms. Treatment can be started only after consulting a doctor and studying the instructions in detail.

Age restrictions for admission

The high effectiveness of the drug has a downside - it has an increased toxic effect on the body.

Therefore, tablets are prescribed to patients over 8 years of age with a body weight of at least 25 kilograms. Children at this age take pills with 25 mg of the active ingredient.

Diclofenac 100 mg tablets can only be taken by adults (from 18 years of age).

In elderly patients, the course of therapy using the drug should occur under the close supervision of a physician and with regular examinations. This approach will help avoid unpleasant side effects of a potent drug.

Instructions for use of Diclofenac tablets

The main rule is that you cannot prescribe the drug yourself, since it may be contraindicated for many people. The instructions indicate the only exception to this rule, when the patient needs it after surgery to reduce tissue swelling.

The tablets are taken orally, they must be swallowed whole, not chewed, and washed down with a small amount of liquid.

Eating does not affect the absorption of the drug, but slightly slows down the process. Therefore, if there is a need for emergency pain relief, it is better to take the tablets half an hour before meals to increase the speed of action. Standard intake - with food or after a meal.

Diclofenac 25 mg tablets

This dosage of the drug is suitable for young patients. Tablets are prescribed to children over 8 years of age weighing more than 25 kg. The daily dose is determined at the rate of 0.3 to 2 mg of active substance per 1 kilogram of the child’s weight and is evenly distributed over 3 doses.

Juvenile rheumatoid arthritis requires an increased dose - up to 3 mg per 1 kilogram. In this case, the maximum permissible amount of the active substance must not be exceeded - 150 mg per day.

Drug 50 mg

14-year-olds and older patients take 1 tablet two or three times a day. The daily dosage should not exceed 150 mg. If treatment is prolonged, the dose is reduced to 75 mg per day.

For painful menstruation, the course of treatment and dose are selected individually. Usually this is no more than two tablets per day immediately after the first signs of dysmenorrhea appear.

Diclofenac tablets 100 mg

The long-acting drug is prescribed only to adult patients.

Dose - no more than one capsule per day. You should take the pill when the pain is especially noticeable: in the morning or at night.

The course of such treatment is no more than 14 days.

Can the drug be used during pregnancy and lactation?

During gestation, it is necessary to take into account the harm that a potent drug can cause to the development of the fetus. Therefore, the doctor prescribes medication only in cases where the need to relieve the symptoms of inflammation is more important than the possible risk.

But the third trimester of pregnancy is an absolute contraindication. Taking medication during this period may cause complications during childbirth. After all, Diclofenac reduces the ability of the uterus to contract and can cause increased bleeding during delivery.

Mothers of infants can use the drug taking into account the correct dosage.

The substance passes into breast milk in small quantities, which does not pose a threat to the baby. However, the decision to prescribe medication is made only by the doctor.

Drug interactions with other drugs

• Anticoagulants and other NSAIDs taken together with the drug increase the risk of internal bleeding.
• The combination of diclofenac sodium and GCS increases side effects in the form of digestive problems.
• The effect of digoxin, phenytoin and lithium drugs is enhanced.
• The effect of antihypertensive, hypnotic, hypoglycemic and diuretic drugs is reduced.
• Paracetamol, cyclosporine and methotrexate increase toxic effects on the kidneys.
• Acetylsalicylic acid reduces the effect of the drug.
• Chylone antibiotics in combination with diclofenac can cause seizures.

Contraindications, side effects and overdose

Tablets should not be taken by people who have categorical prohibitions due to the characteristics of their condition or the presence of certain diseases.

Among them:

• persons with individual sensitivity to the drug;
• couples preparing to conceive;
• patients with hematopoietic dysfunctions;
• people suffering from infertility;
• children under 8 years of age (for 25 mg tablets), up to 14 years of age (50 mg), up to 18 years of age (retard);
• pregnant women in the 3rd trimester;
• asthmatics;
• "cores";
• people with stomach ulcers, bleeding in the gastrointestinal tract;
• patients with renal or liver failure.

The following list of contraindications is not so categorical, but advisory.

The doctor should prescribe the drug with caution in the following cases:

• high blood sugar or cholesterol;
• hypertension;
• elderly age;
• hyperthermia in children;
• 1st and 2nd trimester of pregnancy;
• anemia;
• lactation period.

The drug has a toxic effect on many body systems. Therefore, the list of side effects indicated in the instructions is impressive.

Among the most likely:

• abdominal pain;
• nausea, urge to vomit;
• flatulence, diarrhea;
• dizziness, general weakness;
• visual impairment;
• disruptions of the menstrual cycle;
• drowsiness, problems falling asleep;
• kidney dysfunction;
• skin rash, eczema;
• tremor;
• decrease or increase in blood pressure;
• anemia.

A dangerous complication of the drug is that it causes a high risk of developing myocardial infarction with long-term treatment. Therefore, therapy should be carried out in minimally effective doses.

An overdose is characterized by severe digestive disorders and headaches, and possible seizures.

Analogs of Diclofenac tablets

Among the complete analogues of the medicine available in the pharmacy network are:

• "Ortofen";
• "Adolor";
• "Arguette";
• "Diklak";
• "Voltaren";
• "Bioran."

They contain diclofenac sodium, only in a different concentration and with other auxiliary components.

Also, doctors, depending on the symptoms of the disease, choose other effective drugs from the group of non-steroidal anti-inflammatory drugs.

• “Ketanov”, “Emodol” with ketorolac;
• “Aertal”, “Zerodol” with aceclofenac;
• “Nimesil”, “Nise” with nimesulide;
• “Imet”, “Ibufen”, “Nurofen” with ibuprofen;
• "Movalgin", "Melbek", "Movalis" with meloxicam.

Medicines cannot be replaced on your own. This can only be done if such a prescription has been made by a doctor. After all, each drug has its own indications and contraindications.